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Corneal confocal findings of a case with Chandler Syndrome

Poster Details

First Author: R.Oltulu TURKEY

Co Author(s):    E. Tinkir Kayitmazbatir   G. Satirtav   N. Zengin   M. Okka     

Abstract Details


To report a case of Chandler Syndrome diagnosed by corneal confocal microscopy.


Necmettin Erbakan University, Meram Faculty of Medicine, Ophthalmology Department.


A 33 year old female presented with a complaint of blurry vision in her left eye for about 3 months. Visual acuity was 10/10 in both of her right and left eye. On biomicroscopic examination there was minimal stromal edema in the left eye with the right eye being normal. Intraocular pressures were 14 mmHg and 15 mmHg respectively. Fundus examinations of both eyes did not reveal any pathology. On detailed examination of the iridocorneal angle, no abnormality was observed. There was no history of previous ocular surgery or trauma. Her medical history was unremarkable.


Corneal confocal microscopy of the left eye revealed epithelial like endothelial cells with hyperreflective nuclei characteristic of Chandler syndrome. Endothelial cell count was within normal limits (2225 cell/mm2). The patient was diagnosed with an early stage of Chandler syndrome without any angle abnormality in gonioscopic examination. She was informed about her disease and recommended to return for regular observations for any progression, angular involvement and glaucoma.


Chandler Syndrome is a subtype of iridocorneal endothelial syndrome (ICE). Confocal microscopy provides detailed cellular imaging and has an important role in making the diagnosis. Although glaucoma is the most known presentation of ICE, corneal edema may be the earliest and the only finding and early diagnosis can establish an effective treatment plan for the affected eye.

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