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Corneal biomechanical parameters during pregnancy

Poster Details

First Author: E.Kurt TURKEY

Co Author(s):    M. Balli   H. Mayali   A. Goker        

Abstract Details


To detect the corneal biomechanical alterations in healthy eyes during normal pregnancy and to observe the relationship between these alterations and pregnancy hormones and their progress after the parturition.


The department of Gynecology and Obstetrics of Faculty of Medicine of Celal Bayar University with ages ranging from eighteen to forty years old and being within the first twelfth week of the pregnancy were included into the study.


Visual acuity and biomicroscopic examination, central corneal thickness (CCT) measurement with ultrasonographic pachymetry (UP), fundus examination and corneal biomechanical characteristic measurements with ORA (Ocular Response Analyser) instrument were performed in all of the cases once every three months until the parturition and in three- to six-month intervals after the parturition. Furthermore, estrogen and progesterone levels were studied in each trimester and after the parturition.


CRF expressing rather the stiffness of the cornea was found significantly lower in pregnant females compared to control group (p=0.034). Intraocular pressure was found lower significantly in pregnant females compared to control group (p=0.00). Mean intraocular pressure tends to decrease during the trimesters of the pregnancy. In central corneal thickness (CCT) measurements, significant increase in the third trimester were detected (p=0.00). When central corneal thickness (CCT) values after the parturition were compared with first trimester period, they were found lower in statistically significant level (p < 0.001).


Either the increase in hormone levels in pregnancy or the impairment of the balance between hormones leads to alterations in corneal biomechanics. CH demonstrates more resistive alterations to hormonal alterations compared CRF. It will be convenient to make evaluations by considering alterations of central corneal thickness, intraocular pressure and CRF changes in the corneal diseases detected either during pregnancy or in those existing before pregnancy and the monitoring of glaucoma.

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