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Simultaneous topography-guided PRK with CXL versus CXL alone: a long term comparative clinical and in vivo confocal microscopy study

Poster Details

First Author: G.Kontadakis GREECE

Co Author(s):    G. Kymionis   V. Kankariya   A. Plaka   I. Pallikaris     

Abstract Details


The purpose of this study was to compare corneal collagen crosslinking (CXL) with simultaneous topography-guided PRK and CXL (t-CXL) for progressive keratoconus


Institute of Vision and Optics, University of Crete, Heraklion, Greece


This was a prospective comparative case series.30 eyes received t-PRK (maximum ablation 50μm) followed by CXL, and 30 eyes received CXL


Mean follow up was 31.8±9.2 months. Preoperatively CDVA in t-CXL group was 0.26±0.17 (LogMAR) and in CXL group 0.24±0.18.At last follow up CDVA was 0.09±0.10 in t-CXL group and 0.15±0.12 in CXL group (p<0.05). No patient lost more than 1 CDVA line.In the t-CXL group 19 eyes and in the CXL group 8 eyes gained 2 or more CDVA lines.Keratometry and UDVA were also significantly better in t-CXL group.Depth of CXL treatment, by confocal microscopy, was 269.8±31.8μm in the CXL group and 299.7±29.8 in the t-PRK-CXL group (p<0.001)


Simultaneous t-CXL improved significantly visual function in comparison with CXL. It seems to be a promising treatment, capable of offering keratoconus patients improved vision in comparison to CXL alone, and also halt the progression of the disorder.

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