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Corneal collagen cross-linking for the treatment of pellucid marginal degeneration

Poster Details

First Author: n.cagil TURKEY

Co Author(s):    O. Sarac   M. Caglayan   S. Uysal   E. Akcay     

Abstract Details


To report the visual, refractive, topographic, and clinical outcomes 12 months after corneal collagen cross-linking (CXL) in eyes with pellucid marginal degeneration (PMD).


Center of Keratoconus and Refractive Surgery, Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.


This retrospective study included all consecutively treated PMD patients (15 eyes of 10 patients) with 12 months follow-up period following CXL. The outcome measures were uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), sphere and cylinder on subjective refraction, spherical equivalent, central corneal thickness (CCT), corneal thickness at the thinnest point (t-CCT), simulated flattest keratometry (Sim-K1), simulated steepest keratometry (Sim-K2), average K, apical K, keratoconus vertex front (KVf), and symmetry index front (SIf). The Sirius 3D topography system (CSO, Florence, Italy) was used for the corneal topographic analysis. Follow-up examinations were arranged at 3, 6, and 12 months.


The mean UCVA, BCSVA, spherical value on subjective refraction, spherical equivalent, Sim-K1, Sim-K2, average K, apical K, SIf, and KVf did not show significant change throughout the follow-up period (p>0.05 for all variables). The mean cylinder on subjective refraction and the mean topographic cylinder showed slight decrease which were statistically insignificant throughout 12 months (p>0.05 for all variables). There was not any significant difference between the mean baseline and final CCT and t-CCT (p>0.05 for both variables) values. No complications were occurred.


12 month results after CXL in PMD patients demonstrated stable visual acuity, stable refraction, and stable corneal topographic parameters. More studies with longer follow-up periods are needed to assess the duration of the stability of the corneal ectasia in these patient group. Continued stability of the visual outcome and lack of progression of corneal ectasia can make CXL an alternative therapy in PMD.

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