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Depth of corneal collagen crosslinking demarcation line according to different types of riboflavin solutions

Poster Details

First Author: B.Bozkurt TURKEY

Co Author(s):    A. Mesen   U. Kamis   B. Ekinci-Koktekir   S. Okudan     

Abstract Details


To compare the depth of corneal stromal demarcation line after corneal collagen crosslinking (CXL) according to different types of riboflavin solutions using anterior segment optical coherence tomography (OCT).


University Hospital, Ophthalmology Department


Thirty-three eyes of 27 patients (13 male, 14 female) with progressive keratoconus who underwent CXL treatment according to standard Dresden protocol within 1 year period were enrolled in the study. Isotonic riboflavin with dextran, without dextran and transepithelial (TE) riboflavin solutions were used in 18 eyes, 9 eyes and 6 eyes, respectively. Corneal demarcation line depth was measured centrally by 2 different operators (BB and AM) who were blind to riboflavin solutions and the treatment period using anterior segment OCT (Spectralis, Heidelberg Engineering, Germany).


Mean keratometric values (K1, K2) and central corneal thickness were 46.8+2.5 D, 51.1+3.1 D and 446+28.4 μm, respectively. Stromal demarcation line could be detected in 25 eyes (75.8%). Mean demarcation depth was 247.8+43.9 μm within a range of 179 and 358 μm. Mean depth was shallower in TE solution compared to isotonic riboflavin with and without dextran solution; however the difference was statistically insignificant (p>0.05). The time period after CXL treatment was statistically higher in eyes without a demarcation line (7.1+3.1 months) compared to eyes with a detactable demarcation line (3.2+1.7 months) (p<0.05).


Anterior segment OCT is useful in detection of stromal demarcation line after CXL procedure, which is remarkable in the first 3 months period. Although the depth of demarcation line seems to be shallower in TE solutions compared to isotonic solutions with and without dextran, more prospective studies are needed for a statistical significance.

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