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Short-term effects of intravitreal ranibizumab on lens clarity: a lens densitometry study

Poster Details

First Author: M.Sekeroglu TURKEY

Co Author(s):    M. Anayol   B. Bostanci Ceran   P. Yilmazbas        

Abstract Details


To evaluate the short-term effects of single intravitreal ranibizumab injection on the density of lens nucleus.


Ulucanlar Eye Training and Research Hospital, Ankara, Turkey


The lens nucleus density of the patients with diabetic macular edema who underwent a single intravitreal ranibizumab injection were measured by corneal topography (Pentacam HR, Oculus, Inc., Wetzler, Germany) before and one month after the injection. The patients with a previous history of ocular surgery, laser photocoagulation and/or intravitreal injection were all excluded.


Forty-three eyes of 25 treatment-naive patients (16 males, 9 females) with a mean age of 57.0±9.7 years were enrolled in the study. Twenty-six (60.5%) eyes were classified as stage 0, 16 (37.2%) eyes as stage 1 and one (2.3%) eye as stage 2 according to Pentacam Nucleus Staging software (PNS) preoperatively. Seven eyes that had PNS stage 0 initially progressed to PNS stage 1 at one month after the injection. The PNS stages of the 36 eyes remained unchanged. The average nucleus density was 9.58±1.12 preoperatively and 9.80± 1.26 one month after injection (p=0.103).


Lens nucleus densitometry is an objective method for the evaluation of lens clarity. Intravitreal ranibizumab injection seems to cause an increase in the lens nucleus density measurement albeit the difference was not statistically significant. However, further prospective studies are mandatory to establish the long-term effect of intravitreal ranibizumab injection on cataract development process and to ascertain the clinical significance of these changes.

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