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Nepafenac-moxifloxacin combination vs fluorometholone-moxifloxacin combination in reducing inflammation following phacoemulsification cataract surgery

Poster Details

First Author: M.Guzey TURKEY

Co Author(s):    O. Yilmaz   E. Dogan           

Abstract Details


The purpose of this study was to compare the efficacy of nepafenac-moxifloxacin combination with fluorometholone-moxifloxacin combination in the control of ocular inflammation after clear corneal phacoemulsification cataract surgery.


This prospective, randomized, investigator masked, 11-day, single center study was conducted at the outpatient and surgical unit of Department of Ophthalmology, Harran University School of Medicine, Sanliurfa, Turkey.


Ocular examinations were carried out preoperatively and postoperatively on days 1, 4 and 11. 60 patients (30 in each treatment group) undergoing uncomplicated cataract-lens implant surgery by the same surgeon were enrolled and randomized in the study. The baseline parameters were similar in the two study groups. At each visit comprehensive ocular examinations were performed and a 4-point (0 to 3) grading system was used to record findings of the anterior chamber cells, anterior chamber flare, conjunctival hyperemia, corneal edema, ocular discomfort and burning/stinging sensation.


There was no statistically significant difference between the treatment groups in the findings of the ocular inflammation and discomfort at any of the postoperative visits. Both treatment combinations were equally well tolerated.


The results of this study showed that the efficacy of nepafenac-moxifloxacin combination was similar to that of fluorometholone-moxifloxacin combination in the management of post-cataract surgery inflammation. This study suggests that nepafenac may be an alternative to some corticosteroids (fluorometholone). Nepafenac ophthalmic solution may be effectively and safely used to control mild to moderate inflammation after uneventful small incision phacoemulsification surgery.

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