Official ESCRS | European Society of Cataract & Refractive Surgeons

Iontophoretic collagen crosslinking for early and moderate keratoconus – one year results

Session Details

Session Title: Cornea
Session Date/Time: Sunday 22/02/2015 | 08:30-11:00
Paper Time: 08:42
Venue: Hall 2
First Author: : A.Cantemir ROMANIA
Co Author(s): :    D. Chiselita              

Abstract Details


To assess the efficacy of iontophoretic collagen crosslinking with riboflavin and ultraviolet A (UVA) radiation for treatment of early to moderate keratoconus.


Oftaprof Clinic, Iasi, Romania


Fourty eyes of 24 patients with early and moderate keratoconus were included in this study. All patients underwent slit lamp examination and assessment of uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), intraocular pressure, corneal topography, pachymetry, endothelial cell count and corneal biomechanical parameters. Collagen crosslinking was performed without epithelial removal; the corneas underwent iontophoresis imbibition for 5 minutes followed by UVA irradiation for 9 minutes at 10 mW. Patients were reassessed 1, 3, 6 and 12 months after treatment.


Twelve months postoperatively, UCVA increased by 1.12 Snellen lines and BSCVA was improved by 0.9 Snellen lines (P < 0.001). Spherical equivalent refractive error was reduced by 0.78 D, and maximum and mean K values were decreased by 1.07 D and 0.58 D respectively (P < 0.05 for all comparisons). Evidence of regression was present in 88% of treated eyes. Intraocular pressure, endothelial cell count, lens and fundus didn't change significantly at 12 months follow-up.


Iontophoretic collagen crosslinking demonstrated significant improvement in vision with reduction in corneal power and spherical equivalent refractive error in eyes with early and moderate keratoconus. Iontophoretic collagen crosslinking was safe and well tolerated.

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