Official ESCRS | European Society of Cataract & Refractive Surgeons

Is pulsed accelerated collagen cross-linking effective in progressive keratoconus?

Session Details

Session Title: Cornea
Session Date/Time: Sunday 22/02/2015 | 08:30-11:00
Paper Time: 08:36
Venue: Hall 2
First Author: : A.Sherif EGYPT
Co Author(s): :                  

Abstract Details


To evaluate the functional results of using a new pulsed light accelerated collagen cross-linking technique in cases with mild and moderate progressive keratoconus.


Rowad Cornea Center, Giza, Egypt


16 eyes of 11 patients with mild and moderate keratoconus (Krumeich classification) underwent a new high intensity (30Mw/cm2) epithelium –off UVA corneal collagen cross-linking in a pulsed mode (1 second on/1 second off) for 8 minutes utilizing the KXL device (Avedro Inc, Waltham,MS,USA) preceded by 20 minutes pre-soaking with Riboflavin 0.1% solution in 20 % Dextran (Vibex, Avedro Inc, Waltham,MS,USA) Pre-operative evaluation : UCVA, BSCVA, Pentacam corneal analysis(Oculus Optikegerate Gmbh,Wetzler,Germany) Post-operative evaluation: UCVA, BCVA, Pentacam corneal analysis, Anterior segment OCT 3 and 6 months after surgery


At 6 months, the mean average Keratometry (K avg) was reduced from 49,4 ±0.32 D to 48.6±0.71 The mean depth of demarcation line was 231±26µm 7 eyes gained 2 lines of BCVA eyes 5 eyes gained 1 line of BCVA 3 eyes did not gain lines of BCVA One eye lost 2 lines of BSCVA due to severe stromal haze


Accelerated pulsed CXL appears to be effective in stabilizing KC. Longer follow up periods on larger study groups are needed. The safety profile is questionable due to the to the emerging reports of stromal scarring

Financial Disclosure:


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