Official ESCRS | European Society of Cataract & Refractive Surgeons

Trans-epithelial versus epihelium-off corneal collagen cross-linking for progressive keratoconus

Session Details

Session Title: Cornea
Session Date/Time: Sunday 22/02/2015 | 08:30-11:00
Paper Time: 08:30
Venue: Hall 2
First Author: : M.Alfayez SAUDI ARABIA
Co Author(s): :                  

Abstract Details


To compare the safety and efficacy of trans-epithelial to epithelium-off corneal crosslinking for progressive keratoconus.


Academic institution.


In a prospective clinical trial, seventy patients with progressive keratoconus were randomized to undergo corneal cross-linking with intact epithelium (n = 34) or after de-epithelialization (n = 36). The main outcome measure was change in maximum K reading.


With a 3-year follow-up, K max decreased in the epithelium-off group with a mean of 2.4 D and no patient showed evidence of progression. In trans-epithelial group K max increased by a mean of 1.1 D and 20 patients (55%) showed progression of keratoconus.


In this study, epithelium-off was significantly more effective than trans-epithelial corneal crosslinking in halting progression of keratoconus (P < 0.0005).

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