Official ESCRS | European Society of Cataract & Refractive Surgeons

Effects of Propofol, Etomidate and Thiopental on intraocular pressure and hemodynamic responses in phacoemuscification by insertion of laryngeal mask airway

Session Details

Session Title: Special Cases
Session Date/Time: Friday 20/02/2015 | 08:30-10:30
Paper Time: 09:32
Venue: Sadirvan B
First Author: : M.Abrishami IRAN
Co Author(s): :    M. Alipour   A. Derakhshan   R. Pourmazar        

Abstract Details


To evaluate the effects of Propofol, Etomidate and Thiopental administered during phacoemulsification (PE) cataract extraction on intraocular pressure (IOP) and hemodynamic responses with insertion of laryngeal mask airway (LMA).


Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran


In a randomized double blind clinical trial, patients scheduled for PE with general anesthesia were included. Patients were allocated randomly to three groups: Group 1 (n=34): 0.3 mg/kg Etomidate; Group 2 (n=33): 2 mg/kg Propofol; Groups 3 (n=34):4 mg/kg Thiopental. IOP, systolic blood pressure (SBP) and heart rate (HR) were measured before induction as a baseline, 2 minutes after induction (immediately before insertion of LMA), 1 minute and 3 minutes after LMA insertion. BP and HR of patients during the surgery monitored and registered before and after induction and intubation.


In three groups, IOP decreased significantly after injection of drugs and insertion of LMA in comparison to basic values, although IOP after LMA insertion was more than before that. In case of Propofol, the IOP changes between 2 minutes after induction and the baseline was higher than others especially Thiopental (p=0.031). BP declined remarkably after induction (p<0.001) and rose significantly after LMA insertion in all groups except in Propofol group. HR was decreased significantly after induction except in Thiopental.


Propofol prevented IOP increase after induction more than other drugs. Decrease in BP and HR after induction and LMA insertion were remarkable. Thiopental was seemed to be the best drug for controlling cardiovascular parameters, especially HR, and it also prevents IOP rise.

Financial Disclosure:


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