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Evaluation of changes in corneal biomechanical properties at different levels of diabetic retinopathy and after panretinal photocoagulation

Poster Details

First Author: G.Seymenoğlu TURKEY

Co Author(s):    D. Akbulut   C. Cansiz   E. Baser              

Abstract Details


To evaluate the corneal biomechanical properties due to the glycosylated hemoglobin (HbA1C) levels in patients with type 2 diabetes mellitus (DM) and after panretinal photocoagulation in patients with proliferative diabetic retinopathy (PDR) using the ocular response analyzer (ORA).


Celal Bayar University Hafsa Sultan Hospital, Department of Ophthalmology


Measurements were obtained from 101 subjects with type 2 DM, 48 eyes of 30 patients with PDR and 40 healthy control subjects with similar age and sex. Subjects were divided: Group 1: control subjects; Group 2: DM patients with HbA1C less than 7%; and Group 3: DM patients with HbA1C ≥7%, Group 4: PDR patients which had undergone panretinal photocoagulation (PRP). Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc), central corneal thickness (CCT) were measured once in Groups 1,2,3, but before PRP and at months 1,3,6 after PRP in group 4.


CRF was found to be significantly lower in Group 1 and 2 when compared with Group 3 (P values for CRF respectively; Groups 1 and 2=0.63, Groups 1 and 3, and Groups 2 and 3, = 0.01). There was no significant difference in terms of CH. CCT was significantly different between Groups 1 and 3 and Groups 2 and 3 (P = 0.01) but was insignificant between Groups 1 and 2. Both IOPg and IOPcc was not statistically different between Groups 1 and 2, and Groups 2 and 3, but was significantly different between Groups 1 and 3 (P=0.038). There were no significant differences in any of the parameters before and after PRP treatment in any given time point in Group 4.


In poorly controlled diabetics, CRF and CCT are significantly higher compared with those of the healthy subjects and patients with well-controlled diabetes. These values should be taken into account when measuring IOP values in patients with diabetes mellitus. PRP has no effect on corneal biomechanical parameters in patients with PDR.

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