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Effect on intraocular pressure and endothelial cell count after phacoemulsification with 3 different classes of ophthalmic viscoelastic devices: a prospective randomized controlled study

Poster Details

First Author: Z.Pulpattil Areakat SAUDI ARABIA

Co Author(s):    M. Yasmin                    

Abstract Details


To compare effect of three OVDs DisCoVisc, Microvisc, Visthesia on intraocular pressure and endothelial cell count following phacoemulsification.


Department of Ophthalmology, Dr. Sulaiman al Habib Medical group, Riyadh, Saudi Arabia


This randomized prospective clinical study conducted in 44 eyes of 37 patients. All eyes were undergone phacoemulsification by same surgeon. One of the 3 OVDs were used for all steps of surgery. Sodium hyaluronate 1%( Microvisc), Sodium hyaluronate 1.6% and Sodium chondroitin sulphate 4% (DisCoVisc), Sodium hyaluronate1.5% and lidocaine hydrochloride 1%(Visthesia). Exclusion criteria includes age above 75, endothelial dystrophy, history of uveitis, previous intraocular surgery, preoperative IOP above 21. IOP was measured by Goldmann applanation tonometry preoperative, 6hour, 24 hour, 1 week and 1 month post surgery. ECD were measured pre and 1 month post operation using Tomey EM3000.


All 3 groups had increased IOP 6 hour postsurgery. The highest mean IOP was 27mmHg in DisCoVisc group, which persisted in 1stday followup and stabilized in further visits.Mean IOP rise in other 2 groups were minimal 23.8mmHg(Visthesia) and 23.1(Microvisc). Corneal edema was highest in DisCoVisc group which stabilized in 1 week visits, whereas in other 2 groups corneal edema was minimal or absent in 1st postoperative day. Mean Endothelial cell count loss were 9.6% at 1 month followup. The difference between OVD groups were not statistically significant.


All 3 different classes of OVD had immediate intraocular pressure rise with highest in DisCoVisc group which stabilised in 1week followup. Endothelial cell loss were comparable in all 3 groups. Corneal edema associated with DisCoVisc group related to raised IOP and endothelial pumping disturbances in the first week.

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