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Correlating clinical outcomes and experimental results of presbyopia correcting IOLs

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Session Details

Session Title: Pseudophakic IOLs: Multifocal & Accommodative

Session Date/Time: Monday 07/09/2015 | 08:00-10:30

Paper Time: 08:06

Venue: Room 1

First Author: : H.Weeber THE NETHERLANDS

Co Author(s): :    A. Alarcon   D. Chang   P. Piers              

Abstract Details


Experimental results from the lab are often obtained along the lines of the ISO standard (ISO 11979-2: Ophthalmic implants, Intraocular lenses, Part 2: Optical properties and test methods). However, whether these results are representative for clinical results is unclear. In addition, last year the revision of the ISO standard came into effect. The purpose of this study was to compare experimental lab-based results with clinical outcomes.


AMO Groningen, Netherlands


Clinical defocus curves of existing monofocal, multifocal, and extended range of vision IOL designs are analyzed retrospectively. Separately, optical through-focus modulation transfer function (TF-MTF) curves were obtained by measuring lenses in an optical bench using different model eyes. Model eyes included the ISO Model Eye 1 and the ISO Model Eye 2, both of which use green light. In addition, a model eye was used in combination with white light. TF-MTF at different spatial frequencies was compared with clinical defocus curves from 0 to 4 D.


The optical results depend largely on the model eye used in testing. Measurements in ISO Model Eye 1 give results that are different from those obtained in ISO Model Eye 2. For measurements according to the ISO standard, there is generally a poor correlation between TF-MTF and clinical defocus curves. This is due to the fact that ISO requires measurements to be done in green light and at relatively high spatial frequencies. Improved correlation was obtained when MTF was measured in white light, especially when low spatial frequencies were considered.


Standard optical bench measurements according to the ISO standard show poor correlation with clinical defocus curves. This is also true when the new revision of the ISO standard is used. Measurements in white light, using low spatial frequencies better correlate with clinical results.

Financial Interest:

One of the authors is employed by a for-profit company with an interest in the subject of the presentation, One of the authors receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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