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Capsulotomy mainly induces prostaglandin release during femtosecond laser-assisted cataract surgery

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Session Details

Session Title: Interactive Free Paper Session: FLACS

Session Date/Time: Sunday 06/09/2015 | 08:30-10:00

Paper Time: 09:02

Venue: Room 16

First Author: : T.Schultz GERMANY

Co Author(s): :    S. Joachim   H. Dick                 

Abstract Details


Intraocular prostaglandin release was identified to be involved in laser induced miosis during image-guided femtosecond laser-assisted cataract surgery. The purpose of this study was to investigate a possible correlation between intraocular prostaglandin concentrations and separate steps of laser-assisted cataract surgery.


Ruhr University Eye Hospital, Bochum, Germany.


Aqueous humor was collected from 67 patients after laser treatment (only capsulotomy, only fragmentation, or both) and at the beginning of routine cataract surgery. Total prostaglandin levels were measured in all four groups using an enzyme-linked immunoassay.


Higher levels of aqueous humor prostaglandins were detected after capsulotomy in combination with fragmentation (330.6 ± 110.6 pg/mL; P = .01) or only laser capsulotomy (362.4 ± 117.5 pg/mL; P = .01), whereas the control group showed lower values (52.5 ± 8.1 pg/mL). By itself, lens fragmentation did not lead to a prostaglandin increase (186.8 ± 114.0 pg/mL; P = .14).


This study identified the anterior capsulotomy as the main trigger for an intraocular prosta-glandin increase in the aqueous humor immediately after laser-assisted cataract surgery. Optimized energy settings in combination with nonsteroidal anti-inflammatory drugs might prevent the phenomenon of laser-induced miosis.

Financial Interest:

One of the authors gains financially from product or procedure presented

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