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Corneal subbasal nerve density changes after laser in situ keratomileusis with mechanical microkeratome and femtosecond laser

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Session Details

Session Title: LASIK I

Session Date/Time: Sunday 06/09/2015 | 08:00-10:00

Paper Time: 09:09

Venue: Room 11

First Author: : L.Hu CHINA

Co Author(s): :    W. Xie   L. Tang   J. Chen   D. Zhang   P. Yu   J. Qu     

Abstract Details


To compare the corneal subbasal nerve density (SND) changes using corneal confocal microscope after laser in situ keratomileusis (LASIK) with microkeratome and femtosecond laser.


Eye hospital of Wenzhou Medical University, China


It was a prospective clinical study. Sixty eyes of thirty myopes were analyzed. Fifteen patients (30 eyes) underwent LASIK with Moria II microkeratome and the other 15 patients (30 eyes) with 60-KHz IntraLase femtosecond laser. Central, temporal and nasal corneal SND were measured by confocal microscopy and compared before surgery, 1 month, and 3 months after surgery.


SND at three positions all decreased significantly at each time point postoperatively compared to the baseline values (P <0.05) in both groups; nasal SND increased significantly from 1 month to 3 months (P <0.01) in microkeratome group, temporal and nasal SND both increased significantly from 1 month to 3 months (P <0.05) in femtosecond group. There were no significant differences in central SND between two groups (P >0.05), significant differences in nasal SND were found between two groups at 1 month and 3 months (P <0.01) and significant differences in temporal SND were found between two groups at 3 months after surgery (P <0.01).


Peripheral corneal nerve recovery occurred at 1 month after LASIK surgery, femtosecond laser showed better corneal regeneration than microkeratome.

Financial Interest:


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