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Corneal transplantations at the 1st Department of Ophthalmology, AHEPA University Hospital during the period September 2011 to September 2015: an audit

Poster Details

First Author: N. Ziakas GREECE

Co Author(s):    D. Kapantais   A. Lioura   D. Nanas   K. Marinopoulos   A. Chranioti   P. Oikonomidis

Abstract Details


To report the leading indications, techniques, complications and visual outcomes of corneal transplantations from November 2011 to March 2015.


1st Department of Ophthalmology, AHEPA University Hospital.


Retrospective data of 221 corneal transplantations performed at AHEPA University Hospital were reviewed. Indications were classified into nine different groups: Pseudophakic bullous keratopathy, ectasias (keratoconus, keratoglobus), previous graft rejection, Fuchs’ keratopathy, corneal scar (post-traumatic or chemical), microbial keratitis (bacterial and fungal), herpetic keratopathy, corneal dystrophy and other.


The leading indications for corneal transplantations, in order of decreasing frequency were: Pseudophakic bullous keratopathy (n=60 [27.15%]), ectasias (n=51 [23.08%]), previous graft rejection (n=38 [17.19%]), Fuchs’ keratopathy (n=24 [10.86%]), corneal scar (n=17 [7.69%]), microbial keratitis (n=14 [6.33%]), herpetic keratopathy (n=9 [4.07%]), corneal dystrophy (n=4 [1.8%]) and other (n=8 [3.62%]). Regarding the techniques used, the most preferred technique remains penetrating keratoplasty (PK) (n=180 [81.45%]) followed by Descemet's stripping endothelial keratoplasty (DSAEK-DSEK) (n=31 [14.03%]), Descemet's membrane endothelial keratoplasty (DMEK) (n=5 [2.26%]) and Deep anterior lamellar keratoplasty (DALK) (n=5 [2.26%]). Mean best-corrected visual acuity (BCVA) was 1/10 preoperatively and improved to 2.6/10 post-operatively with an average follow-up of 19.17 months. The most common complications were: Graft rejection (n=18 [8.14%]), graft failure (n=12 [5.42%]), partially detached graft (n=5 [2.26%]), glaucoma (n=5 [2.26%]), persistent epithelial defect (n=5 [2.26%]), neovascularization (n=3 [1.36%]), herpetic recurrence (n=2 [0.90%]) and other (n=7 [3.17%]).


Pseudophakic bullous keratopathy still remains the leading indication for corneal transplantation. Ectasias, previous graft rejection and Fuchs’ keratopathy have also remained consistent indications for keratoplasty during the last 4 years. Concerning the novel techniques introduced to the field of corneal surgery, DSEK-DSAEK increased from zero percent in 2010 to 14.03%, while DMEK and DALK increased from zero percent to 2.26%. As far as the visual outcome is concerned, the patients gained a mean of 8 letters on the Snellen chart at a mean follow-up of 19.17 months. Complications were noted in the 25.33% of keratoplasties with graft rejection and graft failure being the commonest. FINANCIAL DISCLOUSRE: NONE

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