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Human papilloma virus infection does not predict response of ocular surface squamous neoplasia to interferon therapy

Poster Details

First Author: S. Palioura USA

Co Author(s):    A. Galor   A. Nanji   M. Joag   G. Nuovo   G. Wang   C. Karp

Abstract Details


To identify the frequency of human papilloma virus (HPV) in ocular surface squamous neoplasia (OSSN), and assess differences in clinical features and treatment response of HPV positive versus negative tumors.


Tertiary ophthalmology referral center- Bascom Palmer Eye Institute, University of Miami


Retrospective case series of twenty-seven patients with OSSN whose biopsy specimens were analyzed for the presence of HPV. Clinical features and response to interferon were analyzed by HPV status. Twenty-one of 27 tumors (78%) were HPV positive. HPV genotypes identified included HPV 16 in 10 (48%), HPV 31 in 5, HPV 33 in 1, HPV 35 in 2, HPV 51 in 2, and a novel HPV in 3 (total 23 as one tumor had 3 genotypes identified). Tumors found in the superior limbus were more likely to be HPV positive (48% vs 0%, P = 0.06) and showed a poor response to topical interferon. HPV 16 positive tumors were larger (68 mm2 vs 34 mm2, P = 0.08) and were more likely to have a papillomatous morphology (50% vs 12%, P = 0.07). HPV positive status was not associated with a response to interferon therapy.


OSSN lesions in the non-exposed superior limbus tend to be HPV positive. A positive response to interferon is independent of HPV status.



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