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Clinicopathologic study of dry eye, trehalose (3%) and hyaluronic acid (0.15%D)

Poster Details

First Author: C.Stangogianni GREECE

Co Author(s):    E. Stangogianni              

Abstract Details


To evaluate the aqueous tear production, degenerated cells and the density of Goblet cells in patients with severe dry eye after Trehaloza 3%/ Hyaluronic acid 0.15% (Thealoz Duo)® treatment.


Laserlens. Ophthalmology Institute. Ioannina-Greece


Prospective, longitudinal and interventional study, involving 40 patients (80 eyes) with severe dryness (Grade III). Eyes were treatment with Trehaloza 3%/ Hyaluronic acid 0.15% (Thealoz Duo)®. Schirmer test, rose bengal, TBUT and conjunctival biopsy (PAS) were realized pre-operatory, on the first and sixth months after treatment.


40 patients (80 eyes) with mean age 45 YO (40-52) were studied. Tear film increases quantitative and qualitative, the intensity of rose bengal staining decreased. The surface of the conjunctiva contains a small density of Goblet cells which increases after 6 months of treatment, stroma have a small inflammatory cell infiltration and in some severe cases involved the epithelium.


This treatment provide symptomatic relief, improve the viscosity, prolongate the tear break-up times and decrease the rose bengal staining in ocular surface after topical instillation. This treatment could be an alternative for severe cases of dryness. FINANCIAL DISCLOUSRE: NONE

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