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Predictive factors of keratoconus progression

Poster Details

First Author: A.Lopes PORTUGAL

Co Author(s):    C. Pedrosa   P. Pego   C. Vendrell   I. Prieto     

Abstract Details


To determine predictive factors of keratoconus progression in patients with keratoconus in our department.


Ophthalmology Department, Fernando Fonseca Hospital, Lisbon, Portugal


Retrospective study of 93 eyes of 53 patients with keratoconus followed in our department. Topographic parameters obtained by Pentacam® were analyzed. We studied the predictive factors for progression of keratoconus cases up to 2-3 stage, with at least two Pentacam® tests done within at least 1 year without surgery during this period (36 eyes, 27 patients). We divided these patients between group with and without progression and having as a criterion for progression the increase of at least 1.50D in the central keratometry. Statistical analysis was performed using the SPSSv22 software. Tests were considered significant at p=0.05 significance level.


Of the 53 patients, 52.8% were male, mean age 23.3 ┬▒ 5.97 years and bilateral keratoconus (76.9%). Of the 36 eyes within our study parameters only 16 progressed, being the only clinical and epidemiological statistically significant parameters the early age at the diagnosis (p=0.045) and the eye rubbing habit (p=0.046). In the evaluation of the progression of topographic parameters statistically significant differences were found in all parameters of the anterior keratometry (p<0.05), Kmax (p=0.001), anterior and posterior astigmatism (p=0.044; p=0.008), ISV (p=0.002), CKI (p=0.001) and Rmin (p=0.001).


A better understanding of patients' characteristics and keratoconus topographic parameters allows a more effective intervention. Early age at diagnosis, eye rubbing habit, anterior keratometry, astigmatism, Kmax, ISV, CKI and Rmin are potential predictors of progression. FINANCIAL DISCLOUSRE: NONE

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