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Long-term refractive outcomes of myopic femtosecond-assisted LASIK combined with prophylactic cross-linking (CXL) to stand-alone

Poster Details

First Author: I.Kontari GREECE

Co Author(s):    A. Kanellopoulos   F. Tzani           

Abstract Details


To evaluate safety, efficacy, and refractive and keratometric stability of myopic femtosecond-LASIK with concurrent prophylactic high-fluence cross-linking (LASIK+CXL) in comparison to standard femtosecond LASIK.

Setting: Clinical and Research Eye Institute, Athens, Greece


140 eyes of consecutive patients with myopic LASIK were recruited. Group-A (LASIK+CXL) represents 65 eyes treated additionally with concurrent prophylactic high fluence CXL. Group-B (Stand-alone LASIK) represents 75 eyes subjected to stand-alone myopic LASIK procedure. The following parameters were evaluated pre-operatively and one-year post-operatively: manifest refractive spherical error (MRSE), refractive astigmatism, spectacle-corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA), and corneal keratometry via Scheimpflug imaging and autorefraction keratometry.


Group-A had postoperative average MRSE -0.23, -0.19 and -0.25D for the 3-, 6-, and 12-month period, compared to -6.75±1.75D preoperatively. Flat keratometry was 37.69, 37.66, and 37.67D for the same period, compared to 43.92 preoperatively, and steep keratometry was 38.35, 38.36, and 38.37D, compared to 45.15D preoperatively. Predictability correlation coefficient 0.975. Group-B had an average postoperative MRSE -0.23, -0.20 and -0.27D for the 3-, 6-, and 12-month period, compared to -5.33±2.34D preoperatively. Flat keratometry was 37.65, 37.89, and 38.02D, compared to 43.15 preoperatively, and steep keratometry was 38.32, 38.57, and 38.66D respectively, compared to 44.03D preoperatively. Predictability correlation coefficient 0.968.


Application of prophylactic cross-linking concurrently with high-myopic LASIK operation appears to contribute to improved refractive and Keratometric stability in comparison to the stand-alone LASIK. The procedure is safe and opens up a new potential for LASIK application in myopic corrections. FINANCIAL DISCLOUSRE: One or more of the authors travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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