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The diagnostic acuity of ocular surface disease index (OSDI) test to determine the tear film and ocular surface changes in patients receiving systemic isotretinoin

Poster Details

First Author: C.Caglar TURKEY

Co Author(s):    E. Senel   E. Sabancilar   M. Durmus        

Abstract Details


To evaluate the ocular surface changes and tear film functions in patients treated with systemic isotretinoin and to assess the diagnostic performance of Ocular Surface Disease Index (OSDI) test to determine the dry eye related to isotretinoin.


Ophthalmology Deparment of Hitit University


Forthy eyes of twenty subjects (15 female/5 male) treated with oral isotretinoin were enrolled in this clinical trial. All patients underwent an ophthalmic examination at baseline and one more time of the treatment process. In each patient, a biomicroscopic ophthalmic examination, non-anesthetized Schirmer test, and tear film break-up time (BUT) were performed. The biomicroscopy was performed to evaluate the grade of the meibomian disfunction. Subjective ocular complaints were scored with an OSDI questionnaire.


The mean age was 21.5±4.5 (15-40) . Schirmer scores did not significantly change by isotretinoin treatment. Schirmer test score was 22±7.7 mm/5 min in the right, 22.8±7.3 mm/5 min in the left eyes, when compared with baseline values (19.86±7.3 mm/5 min, 20.1±7.1 mm/5min). BUT values decreased and OSDI scores significantly increased after treatment (8.4±4.1 in the right eye BUT, 8.7±4.3 in the left eye BUT and 28.37±17.89 for OSDI, respectively, p<0,05). The mean grade of meibomitis was 1.8±0.7. The decreased BUT and increased OSDI scores were significantly correlated with grade of meibomitis and cumulative dose of isotreonin.


Systemic isotretinoin treatment can cause alterations in the tear film and cause dry eye symptoms. The OSDI test can be used as the diagnostic test for patients receiving systemic isotretinoin. FINANCIAL DISCLOUSRE: NONE

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