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A novel drug-eluting intraocular lens

Poster Details

First Author: L.Lamprogiannis GREECE

Co Author(s):    A. Karamitsos   V. Karagkiozaki   S. Logothetidis   S. Dimitrakos   I. Tsinopoulos  

Abstract Details


Design and fabrication of a prototype intraocular drug delivery system consisting of a three-piece acrylic lens and a biocompatible drug eluting thin film on the surface of the lens. Assessment of physical properties, drug release study, sterilization process and in vitro toxicity study.


2nd University Ophthalmology Clinic, Aristotle University of Thessaloniki, Greece Laboratory for Thin Films, Nanosystems and Nanometrology, Physics Department of Aristotle University of Thessaloniki, Greece


A biodegradable organic polymer thin film was developed by the method of spin coating on the surface of 3-piece intraocular lenses. The IOL-thin film systems were studied with the use of AFM and ellipsometry. Release rate of dexamethasone was studied for a period of ten weeks following sterilization with the use of UV radiation. In vitro toxicity study was conducted.


The films formed nanopores, in agreement with previous findings. The ellipsometry study showed transparent samples. The study of drug release demonstrated a smooth release for the first 6 weeks. Sterilization process was successful and no toxicity was recorded during the in vitro study


In vivo studies may confirm these promising results and open a path for commercial application of this technique. FINANCIAL DISCLOUSRE: NONE

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