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Long-term results of accelerated (30mW/cm2) corneal cross-linking for progressive keratoconus in terms of safety and efficacy

Poster Details

First Author: A.Kirmaci TURKEY

Co Author(s):    Y. Yildirim   G. Yalcinkaya   B. Kepez Yıldız   A. Demirok           

Abstract Details


To evaluate the long-term safety and efficacy of accelerated corneal cross-linking (A-CXL) procedure for the treatment of progressive keratoconus over a minimum 6-year follow-up period.


University of Health Sciences Beyoglu Eye Training and Research Hospital, Istanbul, TURKEY


The records of keratoconus patients who underwent epithelium-off A-CXL (30 mW/cm² for 4 minutes with a total energy dose of 7.2 J/cm²) in our clinic between the years of 2012 and 2014 were retrospectively reviewed. The clinical characteristics, pre-and-postoperative uncorrected and corrected distance visual acuities (UDVA and CDVA), manifest refraction values, topographical examination results, and corneal aberrations as well as complications were recorded and analyzed.


Sixty three eyes of 44 patients with mean age of 24.70±4.07 years were included. Thirty two patients completed a minimum 6-years follow-up. The mean CDVA changed from 0.28±0.52 to 0.26±0.58 logMAR; and the mean pachymetry value changed from 466.83±43.57 to 460.72±42.66 microns, postoperatively. At the 6-year follow-up, there was a significant improvement in Kmax (-0.59 D; p=0.025); whereas the change in K1 (-0.25 D; p=0.074) and K2 (-0.17 D; p=0.219) were not statistically significant. No vision-threatening complications occurred. Re-treatment was required in 6 (9.52%) eyes of 4 patients.


Our results demonstrate that A-CXL is an effective and safe treatment method for progressive keratoconus with stable results over a long-term follow-up.

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