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Individualized topgraphy-guided cross-linking for keratoconus: comparison of epi-on/high oxygen to epi-off/room air protocols

Poster Details

First Author: A.Behndig SWEDEN

Co Author(s):    S. Näslund                    

Abstract Details


To compare the efficacy, safety and healing phase of two different Customized Remodeled Vision (CuRV) crosslinking protocols for keratoconus.


Department of Clinical Sciences/Ophthalmology, Umeå University, Umeå, Sweden


In an ongoing single-masked, intra-individually comparing study 25 patients with bilateral progressive keratoconus have so far been treated with bilateral CuRV; one eye with a high-oxygen epi-on protocol, the other eye with an epi-off protocol in room air, which was randomized. Uncorrected (UDVA) and corrected visual acuities (CDVA), low-contrast visual acuities, refractive spherical equivalents (SE), endothelial cell count (ECC) and adverse events were analyzed pre- and post treatment. The discomfort symptoms during the healing phase for each eye was registered during the first week post treatment.


In both protocols, improved UDVA was seen at 1, 3 and 6 months and improved BSCVA att 3 and 6 months. Improved low-contrast visual acuities at 3 and 6 months was seen with the high-oxygen epi-on protocol (p<0.05), but not with the epi-off protocol. The high-oxygen epi-on treated eyes had significantly less pain and light sensitivity during the first week post treatment. The ECC and CDVA remained unchanged. No adverse events occurred.


Our preliminary results indicate that the novel high-oxygen epi-on treatment protocol appears to be a promising alternative to epi-off CuRV. Finalizing the study, including the planned 12-months follow-up will show if this impression is confirmed.

Financial Disclosure:


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