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Evaluation of the seven corneal anterior surface topometric indices before and after cross-linking in patients with keratoconus

Poster Details

First Author: B.Alves De Souza BRAZIL

Co Author(s):    A. Almeida   M. Dias   L. Braga   F. Alves   E. Feijó   A. Pena     

Abstract Details


To investigate seven corneal anterior surface topometric indices before and after cross-linking in eyes with progressive keratoconus at Ophthalmology Hospital of Anápolis since 2017.


Department of Cornea, Ophthalmology Hospital of Anápolis, Anápolis, Goiás, Brazil


We analyzed 21 patients with progressive keratoconus (34 eyes) which underwent cross-linking (CXL), minimum 1-year follow-up, since 2017. Analysis of the seven corneal anterior surface topometric indices: index of surface variance (ISV), index of vertical asymmetry (IVA), index of height asymmetry (IHA), keratoconus index (KI), central keratoconus index (CKI), index of height decentration (IHD) and minimum radius of curvature (Rmin) before and after cross-linking. Data were analyzed using the Statistical Package for Social Sciences (SPSS) software, version 23.0. In parametric data we used T-paired test and in non-parametric data we used Wilcoxon test. P < 0.05 was considered statistically significant.


Thirty-four cases, age average 23.59 (10–43 years). The average ± standard deviation (SD) ISV was 81.47 ± 31.60, IVA was 0.814 ± 0.388, KI was 1.23 ± 0.10, CKI was 1.06 ± 0.56, IHA was 36.23 ± 24.36, IHD was 0.112 ± 0.600, Rmin was 6.09 ± 0.64 before underwent at the cross-linking. After the cross-linking, the average ± SD were: ISV 76.47 ± 29.90, IVA 0.744 ± 0.398, KI 1.20 ± 0.12, CKI was 1.05 ± 0.04, IHA 36.28 ± 30.27, IHD 0.115 ± 0.112, Rmin 6.09 ± 1.20. The ISV, IVA, IHD and Rmin were statistically significant.


The keratoconus and cross-linking can cause important changes in the corneal surface it can be measured through the topometric indices. More studies of topometrics parameters are needed because they could be used in the near future for diagnostic and follow-up criteria in keratoconus patients.

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