Sterilization of a novel, modified, drug-eluting intraocular lens: a comparison of two methods
First Author: L.Lamprogiannis UK
Co Author(s): A. Karamitsos C. Zena T. Kaimakamis N. Ziakas I. Tsinopoulos S. Logothetidis
This study aims to assess the safety and the efficacy of two methods of sterilization of a novel intraocular drug delivery system.
Lab for Thin Films - Nanobiomaterials - Nanosystems - Nanometrology, Department of Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece
A polymeric,biodegradable, dexamethasone-eluting thin film was developed on the surface of acrylic intraocular lenses. The modified lenses were submitted to treatment with ultraviolet radiation for 20 minutes and H2O2 plasma sterilization, as per standard protocol. Imaging and in vitro cell culture studies were performed.
Both techniques proved to be efficient in sterilizing the modified lenses. Plasma treatment caused cracks to the polymeric thin films, which was not noted with ultraviolet radiation.
Both techniques produce satisfactory results in terms of sterilization. Ultraviolet radiation does not affect the structure of the polymeric thin films.