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Limbal stem cell deficiency (LSCD): demographics and clinical features of a large case series

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Session Details

Session Title: Cornea: Medical

Session Date/Time: Tuesday 10/10/2017 | 08:00-10:30

Paper Time: 10:06

Venue: Room 3.6

First Author: : E.Sarnicola ITALY

Co Author(s): :    N. Auteri   B. Genereux   L. Sepsakos   A. Cheung   E. Holland        

Abstract Details


To describe the clinical features and etiologies of patients with LSCD


Cincinnati Eye Institute, Cincinnati, Ohio, USA.


Retrospective charts analysis of 738 eyes of 432 patients that were diagnosed with LSCD at a tertiary referral center between 2002 and 2015. Outcome measures included patient demographics, LSCD etiologies, laterality, coexisting ocular diseases, and performed surgical procedures.


Mean patient age at the first visit was 62 years (range 2-91) and 221 patients were male whereas 211 were female. Diagnosis was bilateral in 70% of the patients. Mean visual acuity at the first visit 20/80 (range NLP-20/20). The main LSCD etiologies were aniridia/variant aniridia (31%), ocular burn (21%), contact lens (17%), Steven-Johnson syndrome (10%), and iatrogenic (6%). Eighty eyes had a hystory of previous failed keratoplasty without ocular surface transplant (OSST). Mean follow-up was 68±55 months. OSST was performed in 251 eyes(34%), and Boston keratoprosthesis in 62 eyes(8%). Cataract (37%) and glaucoma(33%) were the most frequent comorbidities.


LSCD is a heterogeneous disease secondary to a broad number of etiologies, and it is often under-diagnosed. This study reports novel data about demographics and clinical feature

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