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Morphometrical analysis of blebs filtration trabeculectomies vs XEN® implant evaluated by swept source OCT

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Session Details

Session Title: Glaucoma

Session Date/Time: Monday 09/10/2017 | 08:00-10:30

Paper Time: 10:00

Venue: Room 4.1

First Author: : J.Paz Moreno-Arrones SPAIN

Co Author(s): :    B. Castaao Martin   M. Martinez   M. Teus              

Abstract Details


The purpose of this study was to evaluate the morphology of blebs of successfully functioning trabeculectomies and to compare them with the filtering conjunctiva obtained with the XEN® implant, evaluated using the Triton® Swept-Source OCT.




This is a cross sectional observational study. We included 25 eyes (15 from trabs and 10 with XEN® implant) and 23 eyes from healthy eyes without any filtering surgeries (controls). We evaluated the epithelial thickness as well as the height, the hyperreflectivity areas and the hyporreflective spaces (cystic spaces) in all blebs and in the superior conjunctiva of the control eyes using the Tritón® OCT.


Filtering blebs of patients with XEN implants were significantly flatter than in trabeculectomies (bleb height: trabeculectomies, 618 ± 256 μm, XEN implant, 417 ± 183 μm, controls, 244 ± 45 μm) p<0.05. The XEN group did not show subepithelial fibrosis in any case, compared with 40% of cases with fribrosis in the trab group (p<0.05). XEN blebs showed a lower percentage of subepithelial cysts compared with the trab group (20% vs 24%). We did not find statistically significant differences between IOP decrease induced by XEN vs Trab (-8.5 ± 5.3 vs -8.8 ± 5.2 mmHg, p> 0.05).


Filtering blebs obtained by the XEN implant were morphologically different than Trab blebs, but the hypotensive efficacy was very similar in both groups. XEN implant blebs were flatter and its structure closely resembles a healthy conjunctiva.

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