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Evaluation of the biocompatibility of intraocular lens power adjustment using a femtosecond laser

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Session Details

Session Title: Pseudophakic IOLs: Monofocal

Session Date/Time: Monday 09/10/2017 | 16:30-18:00

Paper Time: 17:00

Venue: Room 2.1

First Author: : N.Mamalis USA

Co Author(s): :    L. Werner   J. Nguyen   J. Ludlow   S. Enright   R. Alley   R. Sahler     

Abstract Details


The use of a femtosecond laser to alter the hydrophilicity of targeted areas within an intraocular lens (IOL) creates the ability to build a refractive index shaping lens within an existing IOL. The objective of this study was to evaluate the biocompatibility (uveal and capsular) of IOL power adjustment by a femtosecond laser.


John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA


Six rabbits underwent phacoemulsification with bilater implantation of an IOL. Postoperative power adjustment was performed using the femtosecond laser 2 weeks following implantation, in one eye. The animals were then followed clinically with slit lamp examination for an additional 4 weeks. The rabbits were then euthanized and the globes were enucleated. The globes were bisected coronally and gross examination and photographs from the posterior aspect were performed to assess anterior capsular opacification and fibrosis as well as posterior capsular opacification. After IOL explantation for power measurements, the globes were sectioned and processed for light microscopy following H&E staining.


Slit lamp examination performed after laser treatment showed the formation of small gas bubbles behind the lens, which disappeared within a couple of hours. No postoperative inflammation or toxicity was observed in the treated eyes, and postoperative outcomes, as well as histopathological exams were similar to the non-treated eyes. After explantation, evaluation of the lenses confirmed that the change in power obtained was consistent and within 0.1 diopter of the target.


Consistent and precise power changes can be induced in the optic of commercially available hydrophobic acrylic lenses in vivo, by using a femtosecond laser. Results showed that the laser treatment of the IOLs was biocompatible.

Financial Disclosure:

is employed by a forNONEprofit company with an interest in the subject of the presentation

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