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Corneal densitometry after DMEK vs DSAEK: two-year results

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Session Details

Session Title: Cornea: Surgical I

Session Date/Time: Sunday 08/10/2017 | 10:30-12:30

Paper Time: 11:22

Venue: Meeting Center Room I

First Author: : K.Droutsas GREECE

Co Author(s): :    A. Lazaridis   E. Giallouros   G. Kymionis   W. Sekundo           

Abstract Details


To analyze and compare corneal densitometry (CD) after Descemet membrane endothelial keratoplasty (DMEK) versus Descemet stripping automated endothelial keratoplasty (DSAEK).


Department of Ophthalmology, Philipps-University, Marburg, Germany and the First Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece


Medical records of consecutive DMEK and DSAEK cases (130 and 49 eyes, respectively) were reviewed. A total of 54 DMEK (group 1) and 25 DSAEK cases (group 2) were included after excluding eyes with prior corneal surgery, complicated intraoperative or postoperative course and vision-limiting ocular comorbidities. Age-matched pseudophakic eyes were also included as controls (group 3; n=20). Scheimpflug CD of the optically relevant zones (0-2mm and 2-6mm), best-corrected visual acuity (BCVA) endothelial cell density (ECD) and central corneal thickness (CCT) were evaluated preoperatively and at 3, 6, 12 and 24 months postoperatively.


CD was significantly lower after DMEK compared to DSAEK at 3 and 6 months (P≤0.012), however similar between the two techniques at 12 and 24 months after surgery (P≥0.056). Postoperative BCVA was significantly higher after DMEK for every examination time point (P<0.001). ECD was similar in both groups (P≥0.081). Regression analysis showed an inverse relationship between BCVA and CD after DMEK (P<0.024). However, no statistically significant correlation was found between BCVA and CD after DSAEK (P≥0.39). Finally, the 24-month CD values were similar between the DMEK group and healthy pseudophakic controls (P=0.152).


CD was lower and BCVA higher after DMEK compared to DSAEK in the first 6 postoperative months. Interestingly, while CD reached similar levels in the midterm after both DMEK and DSAEK, BCVA remained significantly better after DMEK.

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