Official ESCRS | European Society of Cataract & Refractive Surgeons
Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Dropless™ vs Less Drops™ pharmaceutical regimens after cataract surgery

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Session Details

Session Title: Cataract Surgery Special Cases

Session Date/Time: Monday 12/09/2016 | 08:00-10:30

Paper Time: 09:34

Venue: Auditorium C6

First Author: : B.Fisher USA

Co Author(s): :    R. Potvin                    

Abstract Details


​To compare the relative effectiveness of the Imprimis Dropless™ (TriMoxiVanc) intraocular solution with the Less Drops™ topical formulation of PredMoxiKeterolac (given for the first week post op) followed by PredKeterolac (given for weeks 2 to 4 after surgery)


All surgeries and follow-up visits were completed at a single site


This was a prospective, randomized, subject-masked contralateral eye study with an active comparator and was approved by an appropriate ethics committee. Twenty-five subjects with uncomplicated cataract who were scheduled for cataract surgery were enrolled. If surgery was uneventful, subjects received a dropless pharmaceutical regimen in one eye and a minimum drop postoperative pharmaceutical regimen in the fellow eye and were followed for 1 month. Measures of interest were the changes in intraocular pressure from baseline and the changes in corneal and macular thickness. Subjects were also asked to evaluate pain perception, visual quality and overall satisfaction.


Average intraocular pressure one day postoperatively was 2 mm higher in the Dropless group, but the difference was not statistically significant (p = 0.055); there was less than 1mm difference at other time points. There was no statistically significant difference in central macular thickness at any time point (p = 0.38). Central corneal thickness was significantly greater one day postoperatively but there was no statistically significant difference between the groups at any time point (p = 0.89). Satisfaction with the surgery was similar for both groups, but significantly more subjects preferred the Dropless regimen for overall experience (p < 0.01).


Cataract surgery completed with the two pharmaceutical regimens was similar in outcome. Significantly more subjects preferred the Dropless regimen, presumably as a function of convenience and because there was no significant downside associated with the greater convenience

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