Official ESCRS | European Society of Cataract & Refractive Surgeons
Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Efficacy of nepafenac and flurbiprofen in maintaining intraoperative mydriasis during phacoemusification: a comparative study

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Session Details

Session Title: Cataract Surgery Instrumentation/Surgical Devices

Session Date/Time: Sunday 11/09/2016 | 10:30-12:00

Paper Time: 10:42

Venue: Hall C1

First Author: : A.Shrivastava INDIA

Co Author(s): :    S. Mushriff   K. Singh   D. Verma              

Abstract Details


To compare the efficacy of Nepafenac (0.1%) with Flurbiprofen (0.03%) in maintaining intraoperative mydriasis during Phacoemulsification Surgery


Tertiary care teaching hospital in central India


This single-centre, double-blind randomized clinical study comprised 60 patients, divided into two groups (30 each), scheduled for Phacoemulsification. They were randomized to receive nepafenac (0.1%) in one group & flurbiprofen (0.03%) in the other. Pre-operatively all patients received tropicamide 0.8% and phenylephrine 5% eye drops 4 times, at an interval of 15 minutes. Surgery in all the cases was done by the same ophthalmologist, with intra-operative epinephrine (1:1000) in the irrigating solution under local anaesthesia. Horizontal pupil diameter was measured with caliper, immediately before the surgical incision, at the end of phacoemulsification, and at the end of surgery


All the patients achieved horizontal pupil diameter ≥ 7mm at the start of surgery. The mean horizontal diameter of pupil at end of surgery was 7.88 ± 0.76 mm in nepafenac group and 7.15 ± 1.00 mm in flurbiprofen group (P- Value =0.003) which was statistically significant. In the nepafenac group, the pupil size at the end of surgery decreased by a mean of 0.55 ± 0.51 mm (range 0-1.5 mm), while in flurbiprofen group the pupil size decreased by a mean of 0.93 ±0.63 mm (range 0 -2mm). This difference was statistically significant (P = 0.016).


The pre-operative use of nepafenac 0.1% eye drops was more effective in maintaining intraoperative mydriasis as compared to flurbiprofen 0.03% during phacoemusification surgery, thereby reducing intraoperative complications and improving surgical outcome.

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