Official ESCRS | European Society of Cataract & Refractive Surgeons
Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


escrs app advert yo advert

Corneal cross-linking for paediatric keratoconus: long-term results

Search Title by author or title

Session Details

Session Title: Cross-Linking

Session Date/Time: Sunday 11/09/2016 | 08:00-09:30

Paper Time: 08:06

Venue: Auditorium A

First Author: : D.Godefrooij THE NETHERLANDS

Co Author(s): :    N. Soeters   S. Imhof   R. Wisse              

Abstract Details


To assess the efficacy and safety of cross-linking in pediatric keratoconus patients and to provide a systematic literature overview regarding this subject.


University Medical Center Utrecht, tertiary referral center for cornea pathology


In this prospective cohort, 54 eyes of 36 pediatric keratoconus patients underwent standard epithelium-off cross-linking. Follow-up measurements taken up to five years after treatment were compared to baseline values. Logistic regression was used to identify the underlying cause in case of progression despite treatment.


At all follow-up visits up to five year, maximum keratometry values improved significantly (mean change at five years -2.06 diopters, P=0.01); moreover, average keratometry, uncorrected distance visual acuity and corrected distance visual acuity improved at all follow-up moments, though not always to the level of statistical significance. In twelve eyes (22%) keratoconus had progressed by ≥1.0 D by the last follow-up visit, despite corneal cross-linking. Cones that were more decentralized were identified as the underlying cause of disease progression.


Our long term follow-up reveals that epithelium-off cross-linking is both safe and effective when used to prevent keratoconus progression in pediatric patients. However, disease progression occurred in 22% of the treated eyes; this progression was attributed to a more decentralized cone location.

Financial Disclosure:


Back to previous