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Study overcorrection after application of mitomycin C (MMC) in patients undergoing LASEK

Poster Details

First Author: J.Garrido Linares SPAIN

Co Author(s):                  

Abstract Details


To study whether there overcorrection and whether the degree of this is correlated with age in patients undergoing laser subepithelial keratomileusis (LASEK) after topical application of MMC 0.02%.


: Clinica Baviera, Instituto Oftalmológico Europeo, Málaga, Spain.


A retrospective study of 180 eyes undergoing LASEK surgery with a follow-up period of 12 months. Inclusion criteria: spherical equivalent (SE) treated between -1.5 and -9 D, central corneal thickness > 460 microns, without prior systemic or ocular pathology. There were two groups of 90 eyes one of which was applied topically MMC 0.02% for 15 seconds after the laser treatment. The group that the MMC was applied to divide it into two, depending on age. One of ≥ 40 years and one <40 years. We studied whether the overcorrection was related to the patient's age.


180 eyes studied. In the group of 90 eyes which had no MMC applied, SE treated medium was -3.07 ± 0.87 D and -6.85 ± 0.78 D in the group with MMC applied. Within this group, the group treated EE ≥ 40 years was -6.42 ± 0.34 D and -7, 02 ± 0.45 D in the <40 years. At 12 months, the SE is 0.48 ± 0.43 D in the MMC group, with 0.57 ± 0.45 in the group ≥ 40 years and 0.34 ± 0.12 D in the group <40 years. The SE was 0.13 ± 0.11 D in the control group. Neither haze developed eyes.


MMC 0.02% for 15 seconds induces an average overcorrection 0.48 ± 0.43 D. This overcorrection is higher (0.57 ± 0.45 D) in patients ≥ 40 years than in those < 40 years (0.34 ± 0.12 D). The MMC 0.02% for 15 seconds is effective against the development of haze.

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