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Comparison of diagnostic capability of macular ganglionic cell complex and retinal nerve fiber layer in perimetric versus preperimetric glaucoma

Poster Details

First Author: N.Barua INDIA

Co Author(s):    S. Goel   C. Sitaraman   A. Mathur   M. Singh   S. Mukherjee   H. Parashar

Abstract Details


Ganglion cell complex (GCC) is the target for initial cell death in glaucoma. Thinning increases as disease progesses. OCT a reliable, reproducible preperimetric tool helps in diagnosing disease earlier than detectable visual field loss. The study aimed at analyzing structural changes and their correlation with visual field sensitivity (MD) among perimetric ( Primary open angle glaucoma) and preperimetric glaucoma (Ocular hypertension) . We also intended to compare the predictive value of each of the parameter in each group.


: Anand Hospital and Eye Centre, Jaipur


Single day cross sectional study. 40 patients were enrolled in each group after consent. Patents’ have undergone applation tonometry, pachymetry by OCT (RT-Optovue), gonioscopy, visual field analysis (HFA-2) and OCT (RT-optovue) were done . In OCT 5 parameters of macular GCC : average, superior, inferior, Focal and Global loss of volume and 3 parameters of retinal nerve fiber layer : average, superior, inferior were recorded. Data analysed with SPSS, ANOVA, T test, pearson’s correlation. Patients were divided into 2 groups: POAG/OHT, EARLY POAG/OHT and ROC was calculated for each parameter in each subgroup.. the second group were included to detect which parameter was more diagnostic early cases (MD< 6dB).


All group were age and sex matched. POAG patients had a statistically significant thinner GCC, RNFL thickness compared to OHT population. (T test, p is 0.00, p<0.05). There is strong negative correlation between all parameters except FLV and GLV is positively correlated. In POAG/OHT group AUC were .820 for GCC average, .776 for GCC superior, .825 for GCC inferior, .669 for FLV, .743 for GLV, .744 for RNFL average, .671 for RNFL superior, .738 for RNFL inferior . In POAG/OHT population only Inferior GCC had statistically significant AUC value (.715).


GCC and RNFL thickness become thinner as the disease progresses, Focal and global loss of volume increases (P
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