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CXL outcome analysis in the treatment of progressive keratoconus based on findings of optical coherent tomography

Poster Details

First Author: H.Solodkova RUSSIA

Co Author(s):    I. Melikhova              

Abstract Details


To evaluate corneal collagen crosslinking results in treatment of progressive keratoconus basing on findings of anterior segment optical coherent tomography


: S.Fyodorov Eye Microsurgery Federal State Institution Volgograd branch


there were followed 25 patients (25 eyes) with progressive keratoconus of the I-III degree who underwent CXL with a customized excimer laser deepithelialization to the depth of 2/3 of the epithelial layer. Mean patients’ age was 26±13 years. Follow-up period equaled 1, 3, 6 and 12 months. All patients were subject to an extended ophthalmological examination with anterior segment OCT (OCT RS-3000, Nidek, Japan). Preoperative findings were as follows: NCVA averaged 0,15 ± 0,03, BCVA – 0,45 ± 0,06, mean pachymetric value - 465,5 ± 25 µm, mean corneal epithelium thickness - 55 ± 0,5 µm.


one month post-surgically OCT revealed a demarcation line in corneal stroma. NCVA averaged 0,2 ± 0,04, BCVA equaled 0,3 ± 0,07. Six-months postoperatively OCT showed that demarcation line had achieved its maximum optical density, first indications of stromal compaction emerged. NCVA equaled 0,2 ± 0,05, BCVA - 0,6 ± 0,05, mean pachymetric value - 455,5 ± 2,0 µm, mean corneal epithelium thickness - 55 ± 0,5 µm. 12 months post-surgically a moderate hyperplasia of corneal epithelium was observed. NCVA equaled 0,4 ± 0,05, BCVA - 0,7 ± 0,06, mean pachymetric value - 475,5 ± 2,0 µm, mean corneal epithelium thickness - 55 ± 0,5 µm.


OCT, performed at different follow-up periods revealed that CXL induced various morphological changes such as epithelial hyperplasia, demarcation line, corneal stroma compaction. Improvement of visual functions and clinical parameters corresponded to intensity of morphological changes

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