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In vitro efficacy of fluoroquinolones against gram-negative ocular isolates

Poster Details

First Author: C.Kanonidou GREECE

Co Author(s):    E. Kanonidou   V. Konidaris   N. Ziakas   L. Papazisis     

Abstract Details


To analyse the spectrum of gram-negative ocular isolates along with their in vitro susceptibility to fluoroquinolones from 2004 to 2010. The widespread use of fluoroquinolones against ocular infections has lead to the emergence of antibiotic-resistant microorganisms and to a steadily decrease of their in vitro potency.


Department of Ophthalmology, General Hospital of Veria, Veria, Greece.


A retrospective audit of the medical records of patients treated for keratitis and endophalmitis during 2004-2010 was carried out. Adequate specimens (cornea scrapings, intraocular fluids) were collected prior to antibacterial therapy. The minimum inhibitory concentrations (MICs, ?g/ml) against second- (ciprofloxacin), third- (levofloxacin) and fourth-generation fluoroquinolones (moxifloxacin) were determined by Vitek 2 (Biomerieux, France).


Out of 135 ocular isolates, 36 (27%) were gram-negative. The most commonly isolated gram-negative bacteria were Pseudomonas spp. (50%) followed by E. coli (14%) and Enterobacter spp. (13%). No significant changes in the prevalence of gram-negative infections and to the spectrum of bacterial isolates over time were observed. All Pseudomonas spp. isolates were equally susceptible to ciprofloxacin, levofloxacin and moxifloxacin.


The number of ocular infections caused by gram-negative bacteria remained stable over time. All fluoroquinolones tested presented the same in vitro effectiveness against the most common ocular isolate. These laboratory results should be correlated with clinical treatment/outcome studies. FINANCIAL DISCLOSURE?: No

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