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Recovery of visual acuity after photorefractive keratectomy augmented with mitomycin-C

Poster Details

First Author: M.Peyman MALAYSIA

Co Author(s):    H. Razmjoo   M. Kooshanmehr   A. Peyman        

Abstract Details


This study aims to compare 1% and 2% concentrations of Mitomycin-C (MMC) after photorefractive keratectomy (PRK) in terms of recovery of visual acuity


University of Malaya Eye Research Center, Isfahan Eye Research Center


85 patients enrolled in this prospective study. In each subject one eye randomly assigned to group 1 and the second eye to the group 2. Patients underwent surface ablation for treatment of myopia and myopic astigmatism with tissue saving protocol of a Technolas 217z excimer system. In group 1 after ablation Mitomycin-C 1% (0.1mg/ml) solution applied to cornea for 30 seconds, and in group 2 we used Mitomycin-C with concentration of 2% (0.2mg/ml) for 30 seconds before irrigation of the surface and placement of bandage lens. Ocular examination was done before the procedure as well as 1 week, 1, 2, 3 and 6 month after PRK.


Mean spherical equivalent refraction of attempted correction with PRK was -3.16±1.72 diopters (D) (Mean ± Standard deviation). The best corrected visual acuity and mean spherical equivalent refraction were statistically similar for both groups at the latter postoperative time points at 1 week, 1, 3 and 6 month (P>0.05). No statistically difference in uncorrected visual acuity was noted between two groups within the 6 month postoperatively (P>0.05).


Both concentrations of Mitomycin-C appear to be equally effective on visual recovery. Probably using lower concentration of this agent may help to decrease the risk of ocular toxicity. FINANCIAL DISCLOSURE?: No

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