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Comparison of posterior capsule opacification development with 3-piece and 1-piece sharp-edge optic hydrophobic acrylic intraocular lenses: data of five-year prospective clinical trial

Poster Details

First Author: R.Zemaitiene LITHUANIA

Co Author(s):                  

Abstract Details


To evaluate and compare the impact of different design acrylic hydrophobic sharp-edge optic intraocular lenses (IOL) on posterior and anterior lens capsule opacification (PCO and ACO).


Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences


Fifty six eyes of 50 patients having a standard uncomplicated phacoemulsification procedure for age-related cataract were included in a prospective clinical study: 27 eyes with a 3-piece acrylic hydrophobic (AcrySof, MA3OBA) IOL and 29 eyes with a 1-piece acrylic hydrophobic (AcrySof, SA3OAL) IOL. Patients were examined at the slit lamp, visual acuity was determined, and standartized digital retroillumination images of the posterior capsule were taken at 5-year follow-up. The PCO values in the entire IOL optic area and in the central 3-mm optic zone were assessed using a photographic image-analysis system (EPCO2000). The intensity of opacification of anterior capsule leaf on the intraocular lens anterior surface was assessed subjectively. Capsulotomies performed by means of neodymium-yttrium-aluminum-garnet (Nd:YAG) laser were recorded. The eyes treated with Nd: YAG laser capsulotomy were excluded from the EPCO 2000 evaluation.


There were no significant differences in best corrected visual acuity, grade of ACO density and capsulorrhexis/optic overlapping between IOL types during five-year after surgery. There were no significant differences in the PCO values (mean (SD)) either in the entire IOL optic area (3-piece: 0.27 (0.24); 1-piece: 0.16 (0.19)) or in the central 3-mm optic zone (3-piece: 0.14 (0.17); 1-piece: 0.06 (0.11)) comparing the groups at 5-year follow-up. In 9 (33.3%) of 27 eyes with a 3-piece acrylic IOL and 5 (17.2%) of 29 eyes with a 1-piece acrylic IOL had Nd: YAG laser capsulotomy (P=0.13).


Long-term (5-year) follow-up after cataract surgery has shown no difference existence in ACO and PCO development between 3-piece and 1-piece acrylic hydrophobic intraocular lenses. The effect of these foldable lenses in preventing posterior capsule opacification is a result of rectangular, sharp-edged optic design and hydrophobic acrylic biomaterial. FINANCIAL DISCLOSURE?: No

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