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Corneal collagen cross-linking for progressive keratoconus: transepithelial vs conventional method

Poster Details

First Author: M.Verolino ITALY

Co Author(s):    G. Ferrara   A. Tortori   L. Gifuni   L. Capasso   C. Costagliola  

Abstract Details


To compare changes in corneal topography indices after transepithelial with de-epithelialization technique of corneal crosslinking (CXL) in the treatment of keratoconus and analyze associations of these changes with visual acuity.


1UO Oculistica P.O. S. Anna e SS Madonna della Neve, ASL Na 3 Sud; 2UOC Prelievo e Trapianto cornea, P.O. dei Pellegrini, ASL Na 1 Centro; 3Cattedra di Oculistica, Dipartimento di Scienze per la Salute, Universitą degli Studi del Molise


CXL was done in 30 eyes of 30 patients : Group A, transepithelial; Group B, de-epithelized. Uncorrected and best corrected visual acuity (UCVA, BCVA), keratometry, and pachymetry were documented pre- and post-CXL. Follow-up was 3 months. Pain was recorded with a standardized score chart.


Group B patients had pain for the first 3 days whereas patients of Group A did not. There were no significant differences between subgroups. Mean BCVA, Sim K astigmatism, and mean pachymetry values improved from 0.73 ± 0.26 , 5.9 ± 1.8, 432 ± 16 µm to 0.74 ± 0.21, 5.1 ± 2.1, 437 ± 14 µm, respectively in Group A and 0.69 ± 0.3, 5.8 ± 1.7, 434 ± 25 µm to 0.71 ± 0.29 to 5.4 ± 1.2, 437 ± 23 µm, respectively in Group B at 3 months. Improvements in postoperative indices were not correlated with changes in corrected or uncorrected distance visual acuity.


Corneal topography remained stable at 3 months post-CXL. The only significant difference between the two groups was that trans-epithelial CXL provides better patient comfort. FINANCIAL DISCLOSURE?: No

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