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Treatment of large conjunctival lesions by resection and reconstruction using autologous fibrin membrane

Poster Details

First Author: R.Fernandez Buenaga SPAIN

Co Author(s):    A. Rodriguez   P. Casas de Llera   J. Alio        

Abstract Details


To report the use of Autologous Fibrin Membrane to patch large epithelial defects after excised conjunctival lesions in 3 patients


Vissum Corporacion, Alicante, Spain


The 3 patients presented large conjunctival suspicious of malignancy lesions requiring surgical treatment. Under peribulbar anaesthesia and without touching the lesions the surgical management consisted of localized alcohol corneal epitheliectomy, margin resection of the affected conjunctiva and superficial episclerectomy. Supplemental double freeze-thaw cryotherapy to the adjacent remaining conjunctiva followed the procedure. Finally, Autologous Fibrin Membrane was applied over the big epithelial defects to reconstruct the ocular surface. Autologous fibrin membrane was prepared with the patientÂ’s own blood just before surgery and sewn to the rest of the conjunctiva using 8-0 Vicryl sutures. In the postoperative the patients received topical antibiotics and steroidal anti-inflammatory medication. Patients were observed daily for the first 7 days, then weekly and finally monthly.


The epithelization of the bulbar conjunctiva was completed 1 week after the resection. The histopathological diagnoses were Conjunctival melanocytic nevus (13 year old female), Squamous epithelial carcinoma (68 year old male) and primary acquired melanosis (19 year old male). Fibrin Membrane was present covering the defect for the first 5 days, and then gradually disappeared. No evidence of infection or inflammation was detected. No patient suffered recurrences or any postoperative complications at the 6 month follow-up.


The use of Autologous Fibrin Membrane after the resection of large conjunctival lesions is a safe and effective measure for the reconstruction of the conjunctival epithelium after the surgical treatment. This new technique could be used as an alternative to the traditional amniotic membrane reconstruction. FINANCIAL DISCLOSURE?: No

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