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Transepithelial corneal cross-linking with ionthophoresis: first results

Poster Details

First Author: L.Gualdi ITALY

Co Author(s):    V. Cappello   F. Gualdi   M. Gualdi        

Abstract Details


To evaluate the safety and the efficacy of a new method to increase Riboflavin passage into the stroma without the need of epithelial debridment.


D.O.M.A. srl - Rome (Italy) Luca Gualdi


10 eyes were submitted to Transepithelial Corneal Crosslinking with a new Riboflavin formulation and a new device composed by an electric generator (low intensity) connected to two electrodes. This system strongly increases the bioavability of riboflavin into the stroma. The " demarcation line" was studied by anterior segment OCT, tomographies and Confocal microscopy. Digital pictures and short movie will be presented.


No complication was found in therms of visual acuity, pain, polimegatism, pleiomorfism or endotelial cells/mm2 reduction. Long term results will need to confirm also topographically and tomographically decreasing of keratoconus index.


Transepithelial corneal crosslinking with Ionthophoresis is a promising tecnique to perform the surgery without epitelial debridment. The main pros are less pre-operatively imbibition time required (5 minutes) and deeper Riboflavin penetration. FINANCIAL DISCLOSURE?: No

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