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Higher-order aberrations after PRK and LASIK (microkeratome vs femtosecond laser)

Poster Details

First Author: J.Ventruba CZECH REPUBLIC

Co Author(s):    R. Anderle              

Abstract Details


To analyze and compare changes of higher-order aberrations after PRK and LASIK with microkeratome or femtosecond laser at 1, 3, and 12 months postoperatively.


European Eye Clinic Lexum, Czech Republic


Study of 120 consecutive eyes of myopic patients (-0.5 to -6.0D), who underwent standard non-wavefront-guided LASIK with femtosecond laser LDV Ziemer (FS LASIK) (40 eyes), LASIK with microkeratome Amadeus II Ziemer (MK LASIK) (40 eyes) or PRK (40 eyes) using excimer laser MEL 80 Zeiss with iris registration. The average flap thickness with femtosecond laser was 104 μm ± 12 (SD), with microkeratome 105 μm ± 16 (SD). Primary outcome measures were manifest refraction spherical equivalent (MRSE), uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA) and higher-order ocular aberrations (HOAs). HOAs measured with Hartmann-Shack wavefront aberrometer WASCA, HOAs analysed at 6 mm pupil, assessed total HOA root mean square (RMS) and individual Zernike coefficients.


Significant differences were not found between treatment groups in MRSE, UDVA, CDVA or HOAs at postoperative 1 year. As compared with preoperative values, spherical aberration Z(4,0) increased by 0.27 μm (FS LASIK), 0.23 μm (MK LASIK) and 0.27 μm (PRK) (p<0.001), RMS HOAs increased by 0.07 μm (FS LASIK), 0.06 μm (MK LASIK) and 0.03 μm (PRK) (p<0.001) – RMS HOAs was increased following FS LASIK by a factor of 1.28, 1.23 MK LASIK and 1.11 PRK.


LASIK (with femtosecond laser or microkeratome) and PRK only slightly increase RMS HOAs, especially by induction of spherical aberration. All three methods are accurate and safe procedures and have equivalent postoperative aberration score. In comparison with other laser platforms, there is no difference in higher-order aberrations after PRK, LASIK using LDV or Amadeus and MEL 80. FINANCIAL DISCLOSURE?: No

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