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The evaluation of corneal subbasal nerve regeneration with in vivo confocal microscopy in patients on whom FS-LASIK or SMILE was performed

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Session Details

Session Title: Presented Poster Session 16: Small Incision Lenticule Extraction

Session Date/Time: Monday 15/09/2014 | 15:00-17:00

Paper Time: 16:30

Venue: Pod 1 (Poster Village)

First Author: : A.Ağca TURKEY

Co Author(s): :    K. Çankaya   D. Yaşa   Y. Yıldırım   İ. Yılmaz   Ö. Yılmaz   A. Demirok

Abstract Details


To evaluate the postoperative corneal nerve regeneration of the patients whom femtosecond LASIK (FS-LASIK) or small insicion lenticule extraction (SMILE) was performed with in vivo confocal microscopy (IVCM).


Beyoglu Eye Research and Training Hospital


Thirty patients who was treated by SMILE in a eye and FS-LASIK in the other eye were included in this study. The inclusion criteria were; having no contrindications for standart LASIK surgery, a spherical equivalent lower than 10 diopter and having no systemic disease anamnesis. Patients who were treated according to those criteria, were followed up using IVCM (Confoscan 4, Nidek, Italy) 1 week, 1 month, 3 months and 6 months after the surgery. The regeneration of the subbasal nerve plexus, average nerve fiber count and length were evaluated. For statistical analysis, SPSS 20.0 programme was used.


Of the patients, 13 (%43.3) were male and 17 (%56.7) were female. The mean age was 26.58± 4,76 (19-39). The average nerve fiber count of the SMILE group (8,94±3,56/mm²) in the first week follow up was significantly superior to the FS-LASIK group (6,31±4,95/mm²) (p=0,014). There were no significant difference in nerve fiber length between groups in this period. [SMILE: 985,31±565,22 microns/mm², FS-LASIK: 995,31±538,92 microns/mm²; (p=0,929)]. In the 1, 3. and 6. months follow ups, either the nerve fiber length or the nerve fiber count in SMILE group was superior to the FS-LASIK group but the difference was insignificant statistically.


The average nerve fiber count and length in the SMILE group was determined superior to the measurements of the FS-LASIK group especially in the early postoperative period but no significant difference was assigned in the late postoperative period.

Financial Interest:


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