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The EyeDem study: prevalence of cataract and exfoliation syndrome in patients with mild cognitive impairment and dementia

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Session Details

Session Title: Imaging

Session Date/Time: Tuesday 16/09/2014 | 08:00-10:30

Paper Time: 09:50

Venue: Capital Hall B

First Author: : T.Rudolph SWEDEN

Co Author(s): :    M. Zetterberg              

Abstract Details


To investigate a possible relationship between cognitive impairment and eye disease in a case control study


Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden


156 subjects with mild cognitive impairment or early dementia and 40 controls underwent a full ophthalmological examination, including assessment of lens opacities with the lens opacities classification system III (LOCSIII). We used a cutoff-value of 3 on the LOCSIII scale for nuclear and cortical cataract and a cutoff-value of 2 for posterior subcapsular cataract to decide if the patient had clinically significant cataract. Previous cataract surgery was denoted as significant cataract; there were no cases with a history of refractive lens exchange. The presence of XFS was determined at the slit lamp with a dilated pupil.


There were 67.5% females in the control group and 59% in the MCI group (p=0.368, Fisher's exact test). Controls were significantly younger (median 68, range 52-81 years) than MCI patients (median 73, range 55-86 years, p=0.08, Mann-Whitney U test). The prevalence or history of cataract in either eye was equal in both groups (20% vs 20.5%). Exfoliation syndrome was present in 8.3% of the control group and 17.1% of the MCI group (p=0.298, Fisher's exact test).


In our study population, there was no increased prevalence of cataract in patients with MCI or early dementia. The higher rate of XFS in the MCI group was not statistically significant and possibly due to a difference in age distribution.

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