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Optimization of the open-capsule device for PCO prevention

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Session Details

Session Title: PCO

Session Date/Time: Monday 15/09/2014 | 14:30-16:00

Paper Time: 15:46

Venue: Capital Hall B

First Author: : G.Kleinmann ISRAEL

Co Author(s): :    I. Klein              

Abstract Details

Purpose:

To investigate three designs of the Open-Capsule Device for PCO Prevention.

Setting:

Ophthalmology Department, Kaplan Medical Center, Rehovot Israel and Hralan Biotech Israel, Rehovot, Israel.

Methods:

Twenty one New-Zealand rabbit eyes were divided into 3 similar groups after crystalline lens evacuation. Each group was implanted with hydrophilic IOL and hydrophilic open-capsule device of three different designs: Group 1- square design ring with apertures; group 2- square design ring without apertures; group 3- round design ring without apertures. PCO severity was graded weekly by slit-lamp for 6 weeks and by histological evaluation at the end of the study on scale of 0 to 4 (0=clear capsule, 4=severe PCO). Tested groups were compared to control group from previous rabbit trial, consisting of six eyes implanted with hydrophilic IOL only and investigated under same conditions.

Results:

All devices maintained an open capsule and reduced PCO rate, compared to the control group. At the end of the study, the following PCO severity grade was given to groups 1, 2 and 3 respectively: 0.6, 1.6, 1.6 in the slit lamp exam and 0.6, 0.17, 0 in the histological evaluation. This was compared to result of the control group, graded 3.25 in the slit lamp exam and 2.16 in the histological evaluation. Soemmering ring protrusions were observed in all groups, while highest severity was observed in group 3 implanted with rounded design.

Conclusions:

All devices were proven to reduce PCO. Rings of the square design demonstrated advantage over the rounded design. Function of the apertures needs to be investigated further.

Financial Interest:

One or more of the authors... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented, One or more of the authors... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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