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Long-term uveal and capsular biocompatibility and stability after Nd:YAG laser posterior capsulotomy of a new disc-shaped intraocular lens (IOL)

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Session Details

Session Title: PCO

Session Date/Time: Monday 15/09/2014 | 14:30-16:00

Paper Time: 15:00

Venue: Capital Hall B

First Author: : J.Ford USA

Co Author(s): :    J. Kohl   S. Cole   G. Gardiner   S. Vasavada   L. Werner   N. Mamalis

Abstract Details


To evaluate long-term uveal biocompatibility, capsular bag opacification, and stability after Nd:YAG laser capsulotomy, of a new single-piece, hydrophilic acrylic intraocular lens (IOL) suspended between two complete haptic rings connected by pillars of the haptic material.


John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.


Study IOLs were implanted into the right eyes of 8 New Zealand white rabbits; the left eye received a commercially available single-piece hydrophobic acrylic lens. Slit lamp examinations were performed at weeks 1, 2, 4, 6, and 8, and then at months 3 and 6, followed by sacrifice, enucleation, gross examination and histopathology. In a study subset, study lenses were implanted bilaterally in 5 other rabbits. Nd:YAG posterior capsulotomy was performed on the right eyes at 4 weeks postoperatively. Two weeks later, all eyes were enucleated and underwent anterior segment optical coherence tomography (AS-OCT), gross and histopathologic examination.


The 6-month examinations were completed for the 8 rabbits in the long-term study, revealing similar uveal biocompatibility but a significant advantage of the study lens over the control lens in terms of capsular opacification. Central posterior capsule opacification (PCO) was 0.71 +/- 0.26 in the study group and 4 +/- 0 in the control group (P < 0.0001). In the study subset, slit-lamp examination, AS-OCT analysis, and gross and histopathologic analyses showed excellent centration and stability of the study lenses within the capsular bag following Nd:YAG capsulotomy, no evidence of inflammation or toxicity in the eyes, and clear anterior and peripheral posterior capsules.


The new disc-shaped IOL has shown similar uveal biocompatibility to the control lens. The peripheral rings of the study IOL, by expanding the capsular bag and preventing contact with the anterior capsule, appear to prevent opacification of the capsular bag. The lens was also stable after Nd:YAG posterior capsulotomy.

Financial Interest:

One or more of the authors... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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