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Cornea collagen cross-linking for keratoconus in juvenile age group

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Session Details

Session Title: Cross-linking I

Session Date/Time: Monday 15/09/2014 | 14:30-16:30

Paper Time: 14:30

Venue: Capital Hall A

First Author: : H.Razmjoo IRAN

Co Author(s): :    A. Peyman   A. Kamali           

Abstract Details


To evaluate effectiveness of cornea collagen crosslinking (CXL) for keratoconus in patients younger than 18 years of age.


Eye research center, Feiz hospital, Isfahan University of Medical Sciences, Isfahan, Iran


In a prospective clinical study 64 eyes of 37 patients under 18 years of age included. All patients had keratoconus and evidence of progression over past 6 months. Subjects underwent CXL with total epithelial removal and instillation of riboflavin before irradiation with 3mW/cm2 UV for 30 minutes. Patients underwent ophthalmology exam and topography before and 12 months after crosslinking procedure.


Age of the patients was 15.83 +/- 1.53 years (mean +/- SD). 26 (70.3%) of them were male, 14 (37.8%) had positive family history of keratoconus, 11 (29.7%) had history of allergic disorders and 15 (40.5%) had history of notable eye rubbing. Refractive astigmatism decreased significantly from -4.50 +/- 0.29 diopters to -4.11 +/- 0.28 1 year after the procedure (P=0.001). LogMAR uncorrected visual acuity and best corrected visual acuity improved significantly 12 months after CXL (P=0.012 and 0.001 respectively). Maximum keratometry before and after the operation was 53.82 +/- 0.72 and 53.33 +/- 0.72 respectively (P=0.018).


According to our result, CXL improves refracttive, visual, and topographic parameters in patients with keratoconus younger than 18 year old.

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