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Neutrophil to lymphocyte ratio may predict progression in patients with keratoconus

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Session Details

Session Title: Corneal Biomechanics

Session Date/Time: Monday 15/09/2014 | 17:00-18:30

Paper Time: 17:24

Venue: Capital Hall A

First Author: : E.Karaca TURKEY

Co Author(s): :    M. Özmen   F. Ekici   E. Yüksel        

Abstract Details


To evaluate neutrophil to lymphocyte ratio (NLR) of patients with keratoconus, and to analyze the possible difference between stable and progressive keratoconus and normal controls, with a view to contributing our understanding of whether NLR may predict the progression of disease.


Gazi University Medical School, Department of Ophthalmology


This cross-sectional observational study included 54 patients with keratoconus and 25 age and gender matched control subjects. Patients were separated into progressive and non-progressive keratoconus on the basis of topographic progression. All participants underwent a detailed ophthalmological examination and corneal topography. Serum samples were obtained from all subjects and NLR was calculated.


The NLR was 3.27 ± 1.37 in the progressive keratoconus group versus 1.87 ± 0.39 and 1.87 ± 0.52 in non-progressive and control groups, respectively (p<0.01). There was a positive correlation between NLR and progression (p<0.05). In the receiver operating characteristic analysis; a level of NLR ≥ 2.24 predicted the presence of progression with 79% sensitivity and 81% specificity.


NLR is a simple and inexpensive marker of systemic inflammation. NLR increases in progressive keratoconus patients with compared to non-progressive group and controls.

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